IVF – In-vitro Fertilization
IVF is the process of fertilization by manually combining an egg and sperm in a laboratory dish, and then transferring the embryo to the uterus.
DEV IVF Center, the best IVF unit in west district of New Delhi provides you the latest techniques of IVF under the guidance of our medical expertise. The expertise team of DEV have already assisted more than thousands of infertility couples in their past. The Patients who undergo IVF treatment with Team DEV, enjoy the high chance of success.
IVF with Donor Eggs : 70% to 80% couples have positive result in first attempt.
IVF with Self Eggs : 55% to 65% couples have positive result in first attempt.
IVF with Donor Embryos : 80% couples have positive result in first attempt.
We are proud to share that we do all IVF cases with ICSI technique which helps our patient to increase chance of success with very affordable price. IVF (in vitro fertilization) is the most common form of ART (Assisted Reproductive Technology). If the fallopian tubes are damaged or the sperm is poor or has low motility & morphology, it is the only acceptable treatment. It is also usually the most effective treatment for most other types of infertility as well. ICSI provides best fertilization rates of eggs & sperm.
The time period involve only minimum 2 weeks and maximum 3 weeks, It starts from day 2 of female partner’s cycle, where the eggs are fertilized with sperm in IVF lab, and the resulting embryos then are placed into the uterus 2 to 5 days later.
This procedure achieves remarkable pregnancies
– even in women with hopelessly damaged fallopian tubes
– Women that have had tubal ligation
– seemingly sterile husbands
– even “unexplained” infertility
– Male factor infertility (low sperm count or low motility)
– Failed 2-4 cycles of IUI
– Severe endometriosis
– Low AMH
– Being at risk of genetic disease such as cystic fibrosis (IVF with pre-implantation genetic diagnosis — PGD may be indicated )
-Infertility or recurrent pregnancy loss related to chromosomal abnormalities
– IVF is often the treatment of choice for couples in who are experiencing male factor infertility, particularly with intracytoplasmic sperm injection (ICSI), a procedure in which one sperm is injected directly into the egg.
IVF Procedure Involves:
|It starts from day 2 of cycle by stimulating multiple follicles & eggs to develop. Stimulation is done by giving FSH / HMG injections / medications|
|The stimulation process takes approx 12- 15 days.|
|Once eggs are stimulated then EGG COLLECTION is done to collect the eggs from ovaries|
|After that embryologist fertilize the egg by the choosing the best motility sperm by ICSI|
|Minimum time is given 48 hours for embryo development in lab|
|After that last step is Embryo transfer into uterus|
|Once embryo transfer is done then recipient is required to do pregnancy blood test after 12 days.|
|Hundreds of thousands of children are born every year after IVF treatments|
How it helps infertile couples to improve FERTILITY:
|With IVF & ICSI Technique, we remove multiple eggs from ovaries, and after careful culture for 2-5 days of the eggs that fertilize, we transfer one or more of the “prettiest ( A-grade / Best Quality ) embryos” back to the uterus. Which automatically increase the chance of conceiving the pregnancy.|
|After that if there will be any remaining embryos then these embryos will be frozen for next attempt immediately ( if fresh / first attempt does not work )|
|Fertility is improved for many couples that have sperm issues (fertilization defects), or issues on the female side related to egg pickup from the ovary, or tubal transport of the embryo to the uterus or complete tube blockage|
IVF Procedure – Chart
IVF procedure starts from day 2 of cycle (periods). On day 2 of cycle, TVS scan is done to check number of follicles in both ovaries and to check Endometrial thickness ( lining ), shape and size of uterus. This TVS Scan is also done to check cyst and infection if any. On day 2 of cycle, blood test is also done to check hormonal level ( FSH / LH & E2 ). Depending on the reports, doctor starts patient on HMG / FSH injections to stimulate eggs in the ovaries. Stimulation takes approx minimum 12 – 15 days. During this process 3-4 scans are done to keep a close eye on follicles’ progress and size of endometrial thickness. These tests help to predict how well the ovaries are responding. Depending on the scans and blood test, doctor decided the dose of medications and injections.
Monitoring is a strong point under IVF process. A very close and detailed monitoring of follicles / uterus / endometrial thickness is very important base to plan egg collection and embryo transfer. Follicles should have ideal size of 18mm / 19mm / 20mm at the time of egg collection & Endometrial lining should be minimum 8 mm and maximum 12 mm. If the lining is less than 8 mm then there are less chances of success and if lining is 12 mm then also chance of success are on lower side. The ideal lining is 8mm to 12mm. On the day of egg collection, progesterone needs to start to make endometrial lining strong. Once egg collection and ICSI is done, then the embryologist decides the day of embryo transfer depending on the quality / quantity and his experience.
During the close monitoring of follicles and endometrial thickness, the IVF doctor decides the time of egg collection. When eggs have enough size for collection then trigger injection is give to ovaries. A ‘trigger’ injection is then given about 36 hours before the egg collection occurs. This injection contains hormones that loosen the eggs in the follicle and make them ready for collection.
Egg Collection :
The eggs are then collected through a procedure that is performed in a Day Only Unit. Overnight hospital admission is not required for the egg collection procedure. The egg collection is done under ( GA ) General Anesthesia. Under ultrasound the ovaries are scanned through the vagina and a needle is passed through the upper wall of the vagina into the ovary. The follicles in the ovary are then each pierced by the needle and the fluid and egg is removed.
The male will have been asked to ejaculate not more than four days before the day of egg collection to ensure that the sperm on the day is as fresh as possible. Once the eggs have been collected the partner is asked to ejaculate and the sperm provided is prepared for the IVF procedure. When sperm sample is done then the sperm are examined to make sure that sperm sample is good enough to do ICSI.
Embryo Development & Fertilization:
Once the egg collection is done and sperm samples is given by the male partner then embryologist perform ICSI which means embryologist selects a single sperm to be injected directly into an egg ( ICSI helps when you have a very low sperm count & other problems with the sperm have been identified, such as poor morphology (abnormal shape) or poor motility (not moving normally). Fertilization may not occur in all the eggs. Some eggs may fertilize and then disintegrate or not grow normally. The embryologist keeps an eye on the development of the embryos and selects the best one for transfer. You will probably be asked to call after 48 hours of egg collection to find out how many of the eggs fertilized.
Embryo Transfer :
From the day of egg collection, the intended mother is also given Progesterone injection to support endometrial thickness and uterus. The embryo transfer itself is an easy procedure and usually only takes a few minutes. General anaesthesia is not required for embryo transfer. Patient can have a chance to see live embryo transfer in OT. The embryos are picked up in a very thin plastic tube and this is guided through the cervix until it reaches the middle of the uterus where the embryo is deposited. Because the back and front of the uterus are touching each other the embryo will not drop out when you walk around. You can get up straight away after the procedure. Once the transfer is done, the patient is asked to relax for few hours in recovery room. After few hours the patient is ready to go back to home same day.